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pentobarbital will lessen the level or impact of lefamulin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Steer clear of coadministration of lefamulin with powerful or reasonable CYP3A inducers unless the advantage outweighs pitfalls. Observe for diminished efficacy.pentobarbital will lessen the leve